Vicente Felipo Selected Research

GABA Plasma Membrane Transport Proteins

6/2022	Hyperammonemia Enhances GABAergic Neurotransmission in Hippocampus: Underlying Mechanisms and Modulation by Extracellular cGMP.
12/2019	Chronic hyperammonemia alters extracellular glutamate, glutamine and GABA and membrane expression of their transporters in rat cerebellum. Modulation by extracellular cGMP.
1/2019	Peripheral inflammation induces neuroinflammation that alters neurotransmission and cognitive and motor function in hepatic encephalopathy: Underlying mechanisms and therapeutic implications.
5/2017	Sildenafil reduces neuroinflammation in cerebellum, restores GABAergic tone, and improves motor in-coordination in rats with hepatic encephalopathy.
4/2016	Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia.

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Vicente Felipo Research Topics

Disease

64	Hyperammonemia 07/2022 - 05/2002
51	Hepatic Encephalopathy 01/2022 - 12/2005
23	Neuroinflammatory Diseases 05/2022 - 05/2009
19	Liver Failure 09/2015 - 07/2002
18	Cognitive Dysfunction 05/2022 - 06/2004
17	Inflammation (Inflammations) 01/2022 - 08/2007
15	Liver Cirrhosis (Hepatic Cirrhosis) 01/2022 - 02/2002
11	Liver Diseases (Liver Disease) 01/2019 - 02/2002
11	End Stage Liver Disease 07/2009 - 11/2002
7	Fibrosis (Cirrhosis) 01/2022 - 02/2002
7	Acute Liver Failure (Fulminant Hepatic Failure) 06/2014 - 12/2007
7	Tetanus 01/2010 - 12/2002
5	Hypokinesia (Bradykinesia) 06/2013 - 11/2006
4	Ataxia (Dyssynergia) 08/2021 - 09/2015
4	Neurodegenerative Diseases (Neurodegenerative Disease) 09/2015 - 04/2002
3	Alzheimer Disease (Alzheimer's Disease) 12/2019 - 01/2003
3	Brain Edema (Cerebral Edema) 06/2014 - 07/2002
3	Memory Disorders (Memory Loss) 11/2008 - 06/2004
2	Non-alcoholic Fatty Liver Disease 05/2022 - 10/2018
2	Fatty Liver 08/2021 - 10/2018
2	Edema (Dropsy) 02/2011 - 11/2007
2	Ischemia 09/2009 - 04/2002
2	Coma (Comas) 12/2008 - 07/2002
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022
1	Erectile Dysfunction 11/2019
1	Alcoholic Fatty Liver 10/2018

Drug/Important Bio-Agent (IBA)

35	Glutamic Acid (Glutamate)FDA Link 05/2022 - 08/2002
30	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2016 - 02/2002
28	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 07/2022 - 04/2002
28	AmmoniaIBA 01/2022 - 05/2002
11	Proteins (Proteins, Gene)FDA Link 01/2020 - 08/2002
11	Soluble Guanylyl CyclaseIBA 03/2010 - 02/2002
10	N-Methylaspartate (NMDA)IBA 07/2022 - 01/2005
10	gamma-Aminobutyric Acid (GABA)IBA 06/2022 - 04/2009
10	AMPA Receptors (AMPA Receptor)IBA 06/2019 - 04/2007
8	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 01/2018 - 12/2002
8	Cyclic GMPIBA 04/2013 - 08/2005
6	Interleukin-6 (Interleukin 6)IBA 01/2020 - 08/2007
6	Glutamate Receptors (Glutamate Receptor)IBA 01/2020 - 08/2002
6	Sildenafil Citrate (Viagra)FDA Link 01/2019 - 02/2005
6	Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA 01/2015 - 02/2004
6	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 06/2013 - 12/2003
5	GABA Plasma Membrane Transport ProteinsIBA 06/2022 - 04/2016
5	EnzymesIBA 10/2018 - 05/2002
5	Biomarkers (Surrogate Marker)IBA 01/2017 - 03/2006
5	Guanylate Cyclase (Guanylyl Cyclase)IBA 01/2010 - 11/2002
4	Rifaximin (L 105)FDA Link 05/2022 - 01/2019
4	Dinoprostone (PGE2)FDA Link 01/2020 - 08/2010
4	GABA Receptors (GABA Receptor)IBA 01/2020 - 12/2013
4	Glutamine (L-Glutamine)FDA Link 12/2019 - 01/2007
4	CytokinesIBA 01/2019 - 03/2012
4	Ibuprofen (Motrin)FDA LinkGeneric 01/2019 - 08/2007
4	CorticosteroneIBA 08/2013 - 04/2009
3	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA 07/2022 - 12/2015
3	sulforaphaneIBA 01/2019 - 02/2016
3	NitrogenIBA 10/2018 - 12/2005
3	NeurosteroidsIBA 09/2015 - 04/2009
3	p38 Mitogen-Activated Protein KinasesIBA 12/2014 - 11/2011
3	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 12/2013 - 08/2005
3	metabotropic glutamate receptor type 1IBA 06/2013 - 11/2006
3	Atrial Natriuretic Factor (ANF)IBA 02/2013 - 08/2005
3	Interleukin-18 (Interleukin 18)IBA 02/2013 - 03/2009
3	Pharmaceutical PreparationsIBA 11/2011 - 07/2002
3	Calcium-Calmodulin-Dependent Protein KinasesIBA 02/2010 - 08/2008
2	Biological ProductsIBA 01/2021 - 01/2018
2	StrychnineIBA 09/2020 - 01/2016
2	Glycine Receptors (Glycine Receptor)IBA 09/2020 - 01/2016
2	Type I Tumor Necrosis Factor ReceptorsIBA 02/2020 - 01/2020
2	NF-kappa B (NF-kB)IBA 01/2020 - 01/2016
2	Interleukin-10 (Interleukin 10)IBA 01/2020 - 01/2016
2	GlutaminaseIBA 01/2020 - 04/2006
2	PregnenoloneIBA 01/2019 - 04/2013
2	BicucullineIBA 01/2019 - 01/2019
2	Urea (Carbamide)FDA LinkGeneric 10/2018 - 07/2002
2	Peroxynitrous Acid (Peroxynitrite)IBA 01/2018 - 04/2015
2	Infliximab (Remicade)FDA Link 01/2016 - 01/2016
2	Peptides (Polypeptides)IBA 09/2015 - 06/2012
2	Ethanol (Ethyl Alcohol)IBA 02/2015 - 02/2009
2	Dizocilpine Maleate (Dizocilpine)IBA 06/2014 - 11/2007
2	GABA-A Receptors (GABA(A) Receptor)IBA 02/2014 - 05/2002
2	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 12/2013 - 08/2007
2	GuanosineIBA 07/2012 - 02/2002
2	Neurotransmitter Agents (Neurotransmitter)IBA 06/2012 - 12/2005
2	Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA 02/2010 - 08/2008
2	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 02/2010 - 12/2009
2	Polychlorinated Biphenyls (PCBs)IBA 08/2009 - 01/2008
2	AcetylcholinesteraseIBA 11/2008 - 03/2006
2	CalciumIBA 08/2008 - 05/2002
2	3,4-dihydroxyphenylglycolIBA 10/2007 - 04/2007
2	Nitric Oxide Synthase (NO Synthase)IBA 08/2007 - 07/2007
2	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 01/2007 - 05/2004
2	Glutamate-Ammonia Ligase (Glutamine Synthetase)IBA 01/2007 - 12/2005
2	Dihydrotachysterol (AT 10)IBA 12/2005 - 02/2004
1	gephyrinIBA 06/2022
1	Messenger RNA (mRNA)IBA 02/2020
1	Tadalafil (Cialis)FDA Link 11/2019

Therapy/Procedure

21	Surgical Portacaval Shunt (Portacaval Anastomosis) 03/2017 - 11/2004
7	Ligation 02/2015 - 12/2005
2	Therapeutics 05/2022 - 01/2022
2	Transplantation 07/2009 - 09/2008